Norditropin Simplexx Pen 45IU


Norditropin SimpleXx 5mg/1.5ml 15iu
Norditropin SimpleXx 10mg/1.5ml 30iu
Norditropin SimpleXx 15mg/1.5ml 45iu

Manufacturer: Novo Nordisk
Pharmaceutical name: Human Growth Hormone 191aa
Pack: 1 cartridge (45 iu (15mg/1,5 ml))



Norditropin Simplexx Pen 45IU

Norditropin Simplexx Pen 45IU is a polypeptide hormone of recombinant DNA origin. The hormone is synthesized by a special strain of E. coli bacteria that has been modified by the addition of a plasmid which carries the gene for human growth hormone.

Norditropin Simplexx Pen 45IU is a polypeptide hormone of recombinant DNA origin. (check this other hgh of recombinant origin). The hormone is synthesized by a special strain of E. coli bacteria that has been modified by the addition of a plasmid which carries the gene for human growth hormone.

Therapy with Norditropin Simplexx Pen 45IU should be supervised by a physician who is experienced in the diagnosis and management of pediatric patients with short stature associated with GHD, Noonan syndrome, Turner syndrome or SGA, and adult patients with either childhood onset or adult onset GHD.

The Norditropin dosage and administration schedule should be individualized based on the growth response of each patient. Serum insulin-like growth factor I (IGF-I) levels may be useful during dose titration.
Norditropin Simplexx Pen 45IU injection is used to treat growth failure in children and adults who lack natural growth hormone, and in those with chronic kidney failure, Noonan syndrome, Turner syndrome, short stature at birth with no catch-up growth, and other causes. It is also used to prevent severe weight loss in people with AIDS, or to treat short bowel syndrome. It is a form of human growth hormone. Common side effects include headache, nausea, vomiting, fatigue, muscle pain, or weakness.

Norditropin Simplexx Pen 45IU may interact with insulin or oral diabetes medicine, steroids, cyclosporine, seizure medication, birth control pills, anabolic steroids, or hormone replacement medications for men or women. Tell your doctor about all medications you use. Norditropin should be used only when prescribed during pregnancy. It is not known if this drug passes into breast milk. Consult your doctor before breast-feeding.

Norditropin Simplexx Pen 45IU and 10mg (30IU)


Norditropin Simplexx Pen 45IU and 10mg (30IU) solution for injection cartridges are indicated in children with growth problems, Turner’s syndrome, in people with certain kidney problems and in children who are too small for their age.

Norditropin is supplied by Novo Nordisk Limited and contains:

1) histidine
2) hydrochloric acid for pH adjustment
2) mannitol
4) phenol
5) poloxamer 188
6) sodium hydroxide for pH adjustment
7) Somatropin
8) water for injections
Norditropin Simplexx is manufactured using recombinant DNA technology in E. coli secretion expression system.


Caution must be taken if the patient:

1) is a child who has stopped growing completely
2) is over 60 years old
3) is allergic or sensitive to any ingredients
4) is suffering from complications caused by surgery, trauma, or other medical conditions
5) has a respiratory infection, tumor, or kidney problems
6) has diabetes or is at risk for developing diabetes e.g. family history of diabetes, has certain skin problems or is obese
6) has or have had brain or central nervous system problems
7) has pituitary problems
8) has Prader-Willi syndrome
9) has Silver-Russell syndrome
10) has sleep apnoea
Norditropin Simplexx is contraindicated in children under the age of four and in those who are having a kidney transplant.

Drug interaction

The following drugs may interact with Norditropin Simplexx:


The following types of drugs may also interact with Norditropin Simplexx:

anabolic steroids
medicines that are metabolized by the cytochrome P450 system
sex steroids
thyroid hormones
Doctor must be informed if the patients is taking any of the above, or is undergoing treatment with any alternative medicaments, including vitamins, herbal supplements, and non-prescription drugs.


For the best result from Norditropin Simplexx it should be taken in the evening.

Do not use Norditropin Simplexx if the packaging has been tampered with, or if it shows any signs of damage. If you started a cartridge, leave it in the pen. Once opened, store it in a fridge at 2-8°C, and dispose no later than 28 days after opening. You can also store it at the room temperature; however, you must dispose of it 21 days after opening. Store it in the carton box (it is light sensitive), out of the sight and reach of children and pets. Do not freeze, or use after the expiry date shown on the packaging.

Side effects :

In children, side-effects are usually uncommon or rare.

In adults, oedema of the extremities is very common (1 in 10). Less common side effects include headaches, joint pain or stiffness, muscle pain or tenderness and paraesthesia. In addition, carpal tunnel syndrome, diabetes, pain at the injection sites, itching or muscle stiffness is uncommon. On rare occasions skin rash may occur, sometimes in children.

Other symptoms (with unknown frequencies) include:

  1. – abnormal laboratory test results
  2. – bone problems
  3. – ear problems especially in people with Turner’s syndrome
  4. – hypersensitivity reactions
  5. – increase in the size of hands and feet
  6. – increased blood glucose
  7. – intracranial hypertension
  8. – Leukemia
  9. – metabolic problems
  10. – production of anti-Norditropin Simplexx antibodies
  11. – reduced glucose tolerance
  12. – thyroid problems.

You are also check this other type of Norditropin Hgh. It’s also a good Somatropin HGH injection